Castration and sterilization in dogs and bitches: what are the risks to their health?

Article de HartThe purpose of this article is not to “demonize” castration, which has clearly demonstrated benefits in different contexts (see articles: castration in males, breast tumours in cats, breast tumours in dogs, uterine pathologies), but to review current scientific knowledge of demonstrated and/or suspected adverse effects of castration in males and females. 

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Castration and sterilization in male and female cats: interests and risks for their health

Early castration is the surgical removal of gonads (testicles or ovaries) from non-pubescent animals (<4-5 months).
Numerous scientific studies, combined with a decline of more than 20 years in this practice in the United States, show that early castration in cats does not involve more adverse effects than castration at a more traditional age (5 to 8 months).
Nevertheless, this practice remains controversial and confidential in Europe.

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Post-estrus diabetes mellitus (diestrus) in dogs

During diestrus, the physiological increase in plasma progesterone concentration (produced by the corpus luteum) stimulates the production of growth hormone by the hyperplastic ductular epithelium in the breast tissue. The result is transient secondary diabetes mellitus where the sensitivity of target cells to the insulin signal is significantly decreased, resulting in major insulin resistance.
Progesterone and growth hormone disrupt the binding of insulin to its membrane receptors and its regulation (and thus prevent glucose from entering the cells).

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